Fig. 1

Forest plot of Mendelian randomization and Bayesian Model Averaging Mendelian Randomization method of the effect of lipidomes on BC. The OR, P-val, and 95% CI are results obtained from the IVW method, while P-adj represents the outcomes adjusted via the FDR method. The B-OR and B-Pval are results derived from the MR-BMA analysis, and the forest plot displays the IVW results. (Phosphatidylcholine(O-16:1/18:1) represents a specific type of phospholipid molecule with a defined composition. Here is a breakdown of its components: O-16:1: This notation refers to the fatty acid composition of the molecule. In this case, O-16:1 signifies that there is an unsaturated fatty acid with 16 carbon atoms and 1 double bond attached to the glycerol backbone at the first position; 18:1: Similarly, 18:1 denotes an 18-carbon atom unsaturated fatty acid with 1 double bond attached to the glycerol backbone at the second position. In essence, Phosphatidylcholine(O-16:1/18:1) specifies a phospholipid molecule consisting of a choline head group linked to a glycerol backbone, with a 16-carbon unsaturated fatty acid at the first position and an 18-carbon unsaturated fatty acid at the second position. The specific arrangement and composition of these components play a crucial role in the structure and function of the phospholipid within biological membranes. Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylinositol have the same naming principles. Sphingomyelin(d40:2) is a specific type of sphingomyelin lipid molecule. The term "d40:2" refers to the fatty acid composition of the sphingomyelin molecule. In this case, "d40:2" indicates that the sphingomyelin molecule contains a 40-carbon backbone with 2 double bonds. Diacylglycerol(18:1/18:1) refers to a specific type of diacylglycerol lipid molecule. In this case, the notation "18:1/18:1" denotes the fatty acid composition of the two acyl chains attached to the glycerol backbone in the diacylglycerol molecule. Each "18:1" specifies that the fatty acid chain contains 18 carbon atoms and one double bond, also known as an oleic acid. In the context of lipid nomenclature, Triacylglycerol 50:5 is a specific way of expressing the composition of a triglyceride molecule. Here is a breakdown of what this designation means; "50:5" represents the fatty acid composition of the triglyceride molecule. In this case: "50" denotes the total number of carbon atoms in the three fatty acid chains. Therefore, the sum of carbon atoms in all three fatty acids is 50. "5" signifies the total number of double bonds present in the three fatty acid chains combined)